TY - JOUR
T1 - Peptide-Based Inhibitors for SARS-CoV-2 and SARS-CoV
AU - Panchal, Disha
AU - Kataria, Jeena
AU - Patel, Kamiya
AU - Crowe, Kaytlyn
AU - Pai, Varun
AU - Azizogli, Abdul Rahman
AU - Kadian, Neil
AU - Sanyal, Sreya
AU - Roy, Abhishek
AU - Dodd-o, Joseph
AU - Acevedo-Jake, Amanda M.
AU - Kumar, Vivek A.
N1 - Publisher Copyright:
© 2021 Wiley-VCH GmbH.
PY - 2021/10
Y1 - 2021/10
N2 - The COVID-19 (coronavirus disease) global pandemic, caused by the spread of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus, currently has limited treatment options which include vaccines, anti-virals, and repurposed therapeutics. With their high specificity, tunability, and biocompatibility, small molecules like peptides are positioned to act as key players in combating SARS-CoV-2, and can be readily modified to match viral mutation rate. A recent expansion of the understanding of the viral structure and entry mechanisms has led to the proliferation of therapeutic viral entry inhibitors. In this comprehensive review, inhibitors of SARS and SARS-CoV-2 are investigated and discussed based on therapeutic design, inhibitory mechanistic approaches, and common targets. Peptide therapeutics are highlighted, which have demonstrated in vitro or in vivo efficacy, discuss advantages of peptide therapeutics, and common strategies in identifying targets for viral inhibition.
AB - The COVID-19 (coronavirus disease) global pandemic, caused by the spread of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus, currently has limited treatment options which include vaccines, anti-virals, and repurposed therapeutics. With their high specificity, tunability, and biocompatibility, small molecules like peptides are positioned to act as key players in combating SARS-CoV-2, and can be readily modified to match viral mutation rate. A recent expansion of the understanding of the viral structure and entry mechanisms has led to the proliferation of therapeutic viral entry inhibitors. In this comprehensive review, inhibitors of SARS and SARS-CoV-2 are investigated and discussed based on therapeutic design, inhibitory mechanistic approaches, and common targets. Peptide therapeutics are highlighted, which have demonstrated in vitro or in vivo efficacy, discuss advantages of peptide therapeutics, and common strategies in identifying targets for viral inhibition.
KW - SARS-CoV
KW - SARS-CoV-2
KW - SARS-CoV-2 mutants
KW - coronavirus
KW - peptide therapeutics
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U2 - 10.1002/adtp.202100104
DO - 10.1002/adtp.202100104
M3 - Review article
AN - SCOPUS:85111869463
SN - 2366-3987
VL - 4
JO - Advanced Therapeutics
JF - Advanced Therapeutics
IS - 10
M1 - 2100104
ER -