Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

Karthik Sambath, Tinghan Zhao, Zhaoxiong Wan, Yuanwei Zhang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A new class of BODIPY-based oxime ester photo-uncaging group was designed to release carboxylic acids. The mechanism and kinetics of the photo-uncaging procedure were studied. Further, we constructed a photo-uncaging drug delivery system to release valproic acid (VPA), which can inhibit the histone deacetylases and induce apoptosis in tumor cells.

Original languageEnglish (US)
Pages (from-to)14162-14165
Number of pages4
JournalChemical Communications
Volume55
Issue number94
DOIs
StatePublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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