Photocaging of Single and Dual (Similar or Different) Carboxylic and Amino Acids by Acetyl Carbazole and its Application as Dual Drug Delivery in Cancer Therapy

Yarra Venkatesh; Y. Rajesh; S. Karthik; A. C. Chetan; Mahitosh Mandal; Avijit Jana; N. D.Pradeep Singh

doi:10.1021/acs.joc.6b02152

Photocaging of Single and Dual (Similar or Different) Carboxylic and Amino Acids by Acetyl Carbazole and its Application as Dual Drug Delivery in Cancer Therapy

Yarra Venkatesh, Y. Rajesh, S. Karthik, A. C. Chetan, Mahitosh Mandal, Avijit Jana, N. D.Pradeep Singh

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from single chromophore. Mechanistic studies of the photorelease process revealed that photorelease of two (similar or different) substrates from acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive dual drug delivery system (DDS) to release two different anticancer drugs (caffeic acid and chlorambucil, 1 equiv each). In vitro study reveals that our DDS exhibit excellent properties like biocompatibility, cellular uptake, and photoregulated dual drug release.

Original language	English (US)
Pages (from-to)	11168-11175
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	81
Issue number	22
DOIs	https://doi.org/10.1021/acs.joc.6b02152
State	Published - Nov 18 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/acs.joc.6b02152

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title = "Photocaging of Single and Dual (Similar or Different) Carboxylic and Amino Acids by Acetyl Carbazole and its Application as Dual Drug Delivery in Cancer Therapy",

abstract = "A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from single chromophore. Mechanistic studies of the photorelease process revealed that photorelease of two (similar or different) substrates from acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive dual drug delivery system (DDS) to release two different anticancer drugs (caffeic acid and chlorambucil, 1 equiv each). In vitro study reveals that our DDS exhibit excellent properties like biocompatibility, cellular uptake, and photoregulated dual drug release.",

author = "Yarra Venkatesh and Y. Rajesh and S. Karthik and Chetan, {A. C.} and Mahitosh Mandal and Avijit Jana and Singh, {N. D.Pradeep}",

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doi = "10.1021/acs.joc.6b02152",

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AU - Rajesh, Y.

AU - Karthik, S.

AU - Chetan, A. C.

AU - Mandal, Mahitosh

AU - Jana, Avijit

AU - Singh, N. D.Pradeep

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AB - A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from single chromophore. Mechanistic studies of the photorelease process revealed that photorelease of two (similar or different) substrates from acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive dual drug delivery system (DDS) to release two different anticancer drugs (caffeic acid and chlorambucil, 1 equiv each). In vitro study reveals that our DDS exhibit excellent properties like biocompatibility, cellular uptake, and photoregulated dual drug release.

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Photocaging of Single and Dual (Similar or Different) Carboxylic and Amino Acids by Acetyl Carbazole and its Application as Dual Drug Delivery in Cancer Therapy

Abstract

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