Photocaging of Single and Dual (Similar or Different) Carboxylic and Amino Acids by Acetyl Carbazole and its Application as Dual Drug Delivery in Cancer Therapy

Yarra Venkatesh, Y. Rajesh, S. Karthik, A. C. Chetan, Mahitosh Mandal, Avijit Jana, N. D.Pradeep Singh

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from single chromophore. Mechanistic studies of the photorelease process revealed that photorelease of two (similar or different) substrates from acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive dual drug delivery system (DDS) to release two different anticancer drugs (caffeic acid and chlorambucil, 1 equiv each). In vitro study reveals that our DDS exhibit excellent properties like biocompatibility, cellular uptake, and photoregulated dual drug release.

Original languageEnglish (US)
Pages (from-to)11168-11175
Number of pages8
JournalJournal of Organic Chemistry
Volume81
Issue number22
DOIs
StatePublished - Nov 18 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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