Photoresponsive coumarin-tethered multifunctional magnetic nanoparticles for release of anticancer drug

S. Karthik; Nagaprasad Puvvada; B. N.Prashanth Kumar; Shashi Rajput; Amita Pathak; Mahitosh Mandal; N. D.Pradeep Singh

doi:10.1021/am401059k

Photoresponsive coumarin-tethered multifunctional magnetic nanoparticles for release of anticancer drug

S. Karthik, Nagaprasad Puvvada, B. N.Prashanth Kumar, Shashi Rajput, Amita Pathak, Mahitosh Mandal, N. D.Pradeep Singh

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Recently, photoresponsive nanoparticles have received significant attention because of their ability to provide spatial and temporal control over the drug release. In the present work, we report for the first time photoresponsive multifunctional magnetic nanoparticles (MNPs) fabricated using coumarin-based phototrigger and Fe/Si MNPs for controlled delivery of anticancer drug chlorambucil. Further, newly fabricated photoresponsive multifunctional MNPs were also explored for cell luminescence imaging. In vitro biological studies revealed that coumarin tethered Fe/Si MNPs of ∼9 nm size efficiently delivered the anticancer drug chlorambucil into cancer cells and thereby improving the drug action to kill the cancer cells upon irradiation. Such multifunctional MNPs with strong fluorescence, good biocompatibility and efficient photocontrolled drug release ability will be of great benefit in the construction of light-activated multifunctional nano drug delivery systems.

Original language	English (US)
Pages (from-to)	5232-5238
Number of pages	7
Journal	ACS Applied Materials and Interfaces
Volume	5
Issue number	11
DOIs	https://doi.org/10.1021/am401059k
State	Published - Jun 12 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science

Keywords

chlorambucil
coumarin
drug delivery
magnetic nanoparticles
phototrigger

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10.1021/am401059k

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title = "Photoresponsive coumarin-tethered multifunctional magnetic nanoparticles for release of anticancer drug",

abstract = "Recently, photoresponsive nanoparticles have received significant attention because of their ability to provide spatial and temporal control over the drug release. In the present work, we report for the first time photoresponsive multifunctional magnetic nanoparticles (MNPs) fabricated using coumarin-based phototrigger and Fe/Si MNPs for controlled delivery of anticancer drug chlorambucil. Further, newly fabricated photoresponsive multifunctional MNPs were also explored for cell luminescence imaging. In vitro biological studies revealed that coumarin tethered Fe/Si MNPs of ∼9 nm size efficiently delivered the anticancer drug chlorambucil into cancer cells and thereby improving the drug action to kill the cancer cells upon irradiation. Such multifunctional MNPs with strong fluorescence, good biocompatibility and efficient photocontrolled drug release ability will be of great benefit in the construction of light-activated multifunctional nano drug delivery systems.",

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author = "S. Karthik and Nagaprasad Puvvada and Kumar, {B. N.Prashanth} and Shashi Rajput and Amita Pathak and Mahitosh Mandal and Singh, {N. D.Pradeep}",

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AU - Karthik, S.

AU - Puvvada, Nagaprasad

AU - Kumar, B. N.Prashanth

AU - Rajput, Shashi

AU - Pathak, Amita

AU - Mandal, Mahitosh

AU - Singh, N. D.Pradeep

PY - 2013/6/12

Y1 - 2013/6/12

N2 - Recently, photoresponsive nanoparticles have received significant attention because of their ability to provide spatial and temporal control over the drug release. In the present work, we report for the first time photoresponsive multifunctional magnetic nanoparticles (MNPs) fabricated using coumarin-based phototrigger and Fe/Si MNPs for controlled delivery of anticancer drug chlorambucil. Further, newly fabricated photoresponsive multifunctional MNPs were also explored for cell luminescence imaging. In vitro biological studies revealed that coumarin tethered Fe/Si MNPs of ∼9 nm size efficiently delivered the anticancer drug chlorambucil into cancer cells and thereby improving the drug action to kill the cancer cells upon irradiation. Such multifunctional MNPs with strong fluorescence, good biocompatibility and efficient photocontrolled drug release ability will be of great benefit in the construction of light-activated multifunctional nano drug delivery systems.

AB - Recently, photoresponsive nanoparticles have received significant attention because of their ability to provide spatial and temporal control over the drug release. In the present work, we report for the first time photoresponsive multifunctional magnetic nanoparticles (MNPs) fabricated using coumarin-based phototrigger and Fe/Si MNPs for controlled delivery of anticancer drug chlorambucil. Further, newly fabricated photoresponsive multifunctional MNPs were also explored for cell luminescence imaging. In vitro biological studies revealed that coumarin tethered Fe/Si MNPs of ∼9 nm size efficiently delivered the anticancer drug chlorambucil into cancer cells and thereby improving the drug action to kill the cancer cells upon irradiation. Such multifunctional MNPs with strong fluorescence, good biocompatibility and efficient photocontrolled drug release ability will be of great benefit in the construction of light-activated multifunctional nano drug delivery systems.

KW - chlorambucil

KW - coumarin

KW - drug delivery

KW - magnetic nanoparticles

KW - phototrigger

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Photoresponsive coumarin-tethered multifunctional magnetic nanoparticles for release of anticancer drug

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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