Point-of-care diagnostic devices for periodontitis - current trends and urgent need

Alexandra Griffith, Charmi Chande, Sahitya Kulkarni, Josuel Morel, Yu Hsuan Cheng, Emi Shimizu, Carla Cugini, Sagnik Basuray, Vivek Kumar

Research output: Contribution to journalReview articlepeer-review

Abstract

Point of care (POC) diagnostic devices provide a method for rapid accurate identification of disease through analysis of biologically relevant substances. This review focuses on the utility of POC testing for early detection of periodontitis, a critical factor in treating the disease. Accessing the oral cavity for biological sampling is less invasive when compared to other internal test sites, and oral fluids contain biomarkers indicative of periodontitis. The ease of access makes the mouth an excellent target location for the development of POC devices. In this review, accepted standards in industry by which these devices must adhere, provided by the World Health Organization such as REASSURED and CLIA, are discussed. An overview is provided for many periodontal biomarkers currently being investigated as a means of predicting periodontal disease and its progression. POC devices currently being investigated for the identification and monitoring of periodontal disease such as paper-based and lab-on-a-chip based devices are outlined. Limitations of current POC devices on the market are provided and future directions in leveraging biomarkers as an adjunctive method for oral diagnosis along with AI-based analysis systems are discussed. Here, we present the ESSENCE sensor platform, which combines a porous non-planar electrode with enhanced shear flow to achieve unprecedented sensitivity and selectivity. The combination of the ESENCE chip with an automated platform allows us to meet the WHO's ASSURED criteria. This platform promises to be an exciting POC candidate for early detection of periodontitis.

Original languageEnglish (US)
JournalSensors and Diagnostics
DOIs
StateAccepted/In press - 2024

All Science Journal Classification (ASJC) codes

  • Chemistry (miscellaneous)
  • Analytical Chemistry

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