Polyacrylamide Hydrogels for Cell Mechanics: Steps Toward Optimization and Alternative Uses

Casey E. Kandow, Penelope C. Georges, Paul A. Janmey, Karen A. Beningo

Research output: Chapter in Book/Report/Conference proceedingChapter

144 Scopus citations

Abstract

Since their first introduction, polyacrylamide hydrogels have proven to be very useful for studies of mechanical interactions at the cell-substrate interface. In this chapter, we briefly review the basic concepts of this method and provide a series of modifications that have evolved since its inception. In addition, we have described several alternative uses of polyacrylamide hydrogels that have emerged for the study of cellular mechanics. Our intention is to provide users of this gel system with a number of improved and tested options as this method advances toward optimization.

Original languageEnglish (US)
Title of host publicationCell Mechanics
EditorsYuLi Wang, Dennis Discher
Pages29-46
Number of pages18
DOIs
StatePublished - Jul 3 2007
Externally publishedYes

Publication series

NameMethods in Cell Biology
Volume83
ISSN (Print)0091-679X

All Science Journal Classification (ASJC) codes

  • Cell Biology

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