Poly(ethylene glycol) microparticles produced by precipitation polymerization in aqueous solution

Megan M. Flake, Peter K. Nguyen, Rebecca A. Scott, Leah R. Vandiver, Rebecca Kuntz Willits, Donald L. Elbert

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Methods were developed to perform precipitation photopolymerization of PEG-diacrylate. Previously, comonomers have been added to PEG when precipitation polymerization was desired. In the present method, the LCST of the PEG itself was lowered by the addition of the kosmotropic salt sodium sulfate to an aqueous solution. Typical of a precipitation polymerization, small microparticles or microspheres (1-5 ?m) resulted with relatively low polydispersity. However, aggregate formation was often severe, presumably because of a lack of stabilization of the phase-separated colloids. Microparticles were also produced by copoymerization of PEG-diacrylate with acrylic acid or aminoethylmethacrylate. The comonomers affected the zeta potential of the formed microparticles but not the size. The carboxyl groups of acrylic-acid-containing PEG microparticles were activated, and scaffolds were formed by mixing with amine-containing PEG microparticles. Although the scaffolds were relatively weak, human hepatoma cells showed excellent viability when present during microparticle cross-linking.

Original languageEnglish (US)
Pages (from-to)844-850
Number of pages7
JournalBiomacromolecules
Volume12
Issue number3
DOIs
StatePublished - Mar 14 2011

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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