The foaming process and foamed products are of great interest in the manufacturing of drug delivery systems. Physical blowing agents can be used as temporary plasticizers during compounding, allowing the reduction of processing temperature without affecting the product performance. Foaming can be used to produce gastroretentive oral dosages. The milling efficiency of HME products can be improved through foamed structures. However, a correlation between cell-size distribution and particle-size distribution has not been established. API's release rate from solid oral dosages can be accelerated through foaming. However, some of the literature review presented here suggested that the effect of foaming on the dissolution/release rates may depend on the polymer-API pair. Therefore, more polymer-API systems must be studied in order to establish if the effect of foaming is system-dependent or not. In addition, more fundamental knowledge is required to fully understand the correlation between foam cell-size distribution and dissolution/release rates. Finally, studies regarding the impact of foaming on long-term stability of HME products are also required.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Jan 1 2012|
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)
- Polymers and Plastics
- Materials Chemistry