In situ, variable temperature low wavenumber Raman spectroscopy and differential scanning calorimetry together with scanning electron microscope imaging were used to investigate polymorph formation in the non-hydrogen bonded, anti-cholesterol drug fenofibrate (FNB), in the absence and presence of two non-ionic polymeric stabilizers: triBlock copolymer pluronic-F127 (PF/127) and hydroxypropyl methyl cellulose (HPMC/E3). Low wavenumber Raman spectra show that metastable phase II formation occurs on initial cooling to 25 °C following the first heat-up to 100 °C for both pure FNB and FNB in the presence of PF/127, but not in the presence of HPMC/E3. Differential scanning calorimetry results on the other hand show that phase II of FNB crystallizes near 75 °C during the first heat-up of the drug in the presence of PF/127 but was not observed in the pure drug or the drug in the presence of HPMC/E3. These results are discussed in terms of molecular simulations carried out to determine the non-bonded interaction energies between the polymers and FNB.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Raman spectroscopy
- hydroxypropyl methyl cellulose
- low wavenumber