TY - GEN
T1 - Porous surface modified bioactive glass stimulates tissue engineered repair of long bone defects
AU - Ducheyne, Paul
AU - Livingston, Treena
AU - Garino, Jonathan P.
PY - 1999
Y1 - 1999
N2 - Massive bone loss of the proximal femur is a common problem in revision hip arthroplasties. Allograft bone is commonly used to reconstruct the site for fixation of the new prosthesis. However, the long-term function of the prosthesis can be compromised due to the delayed healing or poor remodeling of the allograft. Thus, alternative materials are needed to function not only as mechanical fillers but, to induce bone formation and ultimately, be replaced by and function as normal bone tissue. We have developed a porous, bioactive scaffold that stimulates the expression of the osteoblastic phenotype and production of bone-like matrix in vitro. In this present study, we investigate, mechanically, the incorporation of the scaffold in a long bone defect in the rat.
AB - Massive bone loss of the proximal femur is a common problem in revision hip arthroplasties. Allograft bone is commonly used to reconstruct the site for fixation of the new prosthesis. However, the long-term function of the prosthesis can be compromised due to the delayed healing or poor remodeling of the allograft. Thus, alternative materials are needed to function not only as mechanical fillers but, to induce bone formation and ultimately, be replaced by and function as normal bone tissue. We have developed a porous, bioactive scaffold that stimulates the expression of the osteoblastic phenotype and production of bone-like matrix in vitro. In this present study, we investigate, mechanically, the incorporation of the scaffold in a long bone defect in the rat.
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M3 - Conference contribution
AN - SCOPUS:0033341440
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 750
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -