Porous surface modified bioactive glass stimulates tissue engineered repair of long bone defects

Paul Ducheyne, Treena Arinzeh, Jonathan P. Garino

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Massive bone loss of the proximal femur is a common problem in revision hip arthroplasties. Allograft bone is commonly used to reconstruct the site for fixation of the new prosthesis. However, the long-term function of the prosthesis can be compromised due to the delayed healing or poor remodeling of the allograft. Thus, alternative materials are needed to function not only as mechanical fillers but, to induce bone formation and ultimately, be replaced by and function as normal bone tissue. We have developed a porous, bioactive scaffold that stimulates the expression of the osteoblastic phenotype and production of bone-like matrix in vitro. In this present study, we investigate, mechanically, the incorporation of the scaffold in a long bone defect in the rat.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
Volume2
ISBN (Print)0780356756
StatePublished - Dec 1 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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