TY - JOUR
T1 - PRec-I-DCM3
T2 - A parallel framework for fast and accurate large-scale phylogeny reconstruction
AU - Dotsenko, Yuri
AU - Coarfa, Cristian
AU - Nakhleh, Luay
AU - Mellor-Crummey, John
AU - Roshan, Usman
PY - 2006
Y1 - 2006
N2 - Accurate reconstruction of phylogenetic trees often involves solving hard optimisation problems, particularly the Maximum Parsimony (MP) and Maximum Likelihood (ML) problems. Various heuristics yield good results for these problems within reasonable time only on small datasets. This is a major impediment for large-scale phylogeny reconstruction. Roshan et al. introduced Rec-I-DCMS, an efficient and accurate meta-method for solving the MP problem on large datasets of up to 14,000 taxa. We improve the performance of Rec-I-DCM3 via parallelisation. The experiments demonstrate that our parallel method, PRec-I-DCM3, achieves significant improvements, both in speed and accuracy, over its sequential counterpart.
AB - Accurate reconstruction of phylogenetic trees often involves solving hard optimisation problems, particularly the Maximum Parsimony (MP) and Maximum Likelihood (ML) problems. Various heuristics yield good results for these problems within reasonable time only on small datasets. This is a major impediment for large-scale phylogeny reconstruction. Roshan et al. introduced Rec-I-DCMS, an efficient and accurate meta-method for solving the MP problem on large datasets of up to 14,000 taxa. We improve the performance of Rec-I-DCM3 via parallelisation. The experiments demonstrate that our parallel method, PRec-I-DCM3, achieves significant improvements, both in speed and accuracy, over its sequential counterpart.
KW - Bioinformatics research and applications
KW - DCM3
KW - Disk-Covering Method (DCM)
KW - Maximum Parsimony (MP)
KW - PRec-I-DCM3
KW - Parallel computing
KW - Phylogeny
KW - Rec-I-DCM3
KW - Scalability
UR - http://www.scopus.com/inward/record.url?scp=33846152358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846152358&partnerID=8YFLogxK
U2 - 10.1504/IJBRA.2006.011039
DO - 10.1504/IJBRA.2006.011039
M3 - Article
C2 - 18048181
AN - SCOPUS:33846152358
SN - 1744-5458
VL - 2
SP - 407
EP - 419
JO - International Journal of Bioinformatics Research and Applications
JF - International Journal of Bioinformatics Research and Applications
IS - 4
ER -