Probabilistic neural networks using Bayesian decision strategies and a modified Gompertz model for growth phase classification in the batch culture of Bacillus subtilis

Laurent Simon, M. Nazmul Karim

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Probabilistic neural networks (PNNs) were used in conjunction with the Gompertz model for bacterial growth to classify the lag, logarithmic, and stationary phases in a batch process. Using the fermentation time and the optical density of diluted cell suspensions, sampled from a culture of Bacillus subtilis, PNNs enabled a reliable determination of the growth phases. Based on a Bayesian decision strategy, the Gompertz based PNN used newly proposed definition of the lag and logarithmic phases to estimate the latent, logarithmic and stationary phases. This network topology has the potential for use with on-line turbidimeter for the automation and control of cultivation processes.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalBiochemical Engineering Journal
Volume7
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Environmental Engineering
  • Bioengineering
  • Biomedical Engineering

Keywords

  • Bayesian strategy
  • Bioprocess monitoring
  • Fermentation
  • Growth kinetics
  • Modeling
  • Probabilistic neural networks

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