Process-structure-property relationships of erodable polymeric biomaterials, I: Poly (desaminotyrosyl arylates)

Polymeric biomaterials, especially new compositions, are often tested for biocompatibility, bioerosion rate or cell growth specificity without regard to the morphological structures introduced during materials processing. It will be shown that in addition to the potential influence on biological response, processing induced structure profoundly influences materials properties under biorelevant conditions. Using a combinatorial library of erodable Polyarylates, these issues will be explored with emphasis on in-vivo dimensional stability and mechanical property retention.