Pushing myocardial crossbridges to the limit

William C. Hunter

Research output: Contribution to journalConference articlepeer-review


This study demonstrated that a crossbridge model incorporating multiple shortening steps per ATP hydrolysis cycle is consistent with experimental observations of myocardial dynamic stiffness for oscillation amplitudes that are large (i.e., up to 6%) relative to the molecular scale. Such a model also appears consistent with cardiac energetics, and may offer an improved representation of myocardial actomyosin kinetics.

Original languageEnglish (US)
Pages (from-to)85-86
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Issue number1
StatePublished - 1995
Externally publishedYes
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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