@inproceedings{334b9d6240f24d879569c1c90a02e19b,
title = "Quality Assurance of Concept Roles in the National Cancer Institute thesaurus",
abstract = "Ontologies are integral components of many health information processing environments. Hence, quality assurance (QA) of the conceptual content of any ontology is essential. A methodology for facilitating the identification and correction of a kind of error called 'missing-role error' for ontology concepts is presented. Specifically, being a member of the 'null-role set' is used as an indicator that missing-role errors are likely. Our QA methodology was applied to the Biological Process hierarchy, one of the hierarchies of the National Cancer Institute thesaurus (NCIt), a prominent ontology in the biomedical domain. Two hypotheses pertaining to the effectiveness of our QA approach were investigated. Many missing-role errors were discovered and confirmed in our analysis. In comparison to a control sample, our QA approach yielded a statistically significant number of concepts with missing-role errors, confirming our two hypotheses. QA is a critical part of an ontology's life-cycle, and automated or semi-automated tools for supporting this process are invaluable. The presented approach is a useful addition to the arsenal of tools available to QA personnel.",
keywords = "National Cancer Institute thesaurus, Ontology, Ontology Modeling, Quality Assurance, Role Error",
author = "Ling Zheng and Yan Chen and Yehoshua Perl and Michael Halper and James Geller and {De Coronado}, Sherri",
note = "Funding Information: Research reported in this publication was partially supported by the National Cancer Institute of the National Institutes of Health under Award Number R01CA190779. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2018 IEEE.; 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 ; Conference date: 03-12-2018 Through 06-12-2018",
year = "2019",
month = jan,
day = "21",
doi = "10.1109/BIBM.2018.8621277",
language = "English (US)",
series = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "2001--2008",
editor = "Harald Schmidt and David Griol and Haiying Wang and Jan Baumbach and Huiru Zheng and Zoraida Callejas and Xiaohua Hu and Julie Dickerson and Le Zhang",
booktitle = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",
address = "United States",
}