Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties

Yi Qiu, Yahui Wang, Yiqing Xu, Namas Chandra, James Haorah, Basil Hubbi, Bryan Pfister, Xuan Liu

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allowed us to extract Young’s modulus of biological tissue. We experimentally calibrated our qOCE instrument, and validated its effectiveness on tissue mimicking phantoms and biological tissues.

Original languageEnglish (US)
Article number254870
Pages (from-to)688-700
Number of pages13
JournalBiomedical Optics Express
Volume7
Issue number2
DOIs
StatePublished - Jan 26 2016

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Keywords

  • Laser doppler velocimetry
  • Optical coherence tomography
  • Optical sensing and sensors

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