Radial crossbridge elasticity coupled with thin-filament cooperativity as the basis for the Frank-Starling Law

William Hunter; Yiming Wu; Kenneth Campbell

Radial crossbridge elasticity coupled with thin-filament cooperativity as the basis for the Frank-Starling Law

William Hunter, Yiming Wu, Kenneth Campbell

Research output: Contribution to journal › Conference article › peer-review

Abstract

Combining Hill's statistical-mechanical model of thin-filament cooperativity with an attachment equilibrium dependent on radial spacing yields forcepCa relations that become more sensitive to calcium as attachment becomes more favorable (when radial spacing shrinks toward optimum as sarcomeres lengthen). In a rat skinned trabecula, we measured force-pCa relations while varying radial spacing osmotically. Observations agreed with a unique prediction of this model: 'over' compression (beyond optimum) shifts forcepCa rightward.

Original language	English (US)
Pages (from-to)	S-60
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Externally published	Yes
Event	2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000

All Science Journal Classification (ASJC) codes

Biomedical Engineering

Cite this

@article{37ebe5496bf446caba52d87f136433a6,

title = "Radial crossbridge elasticity coupled with thin-filament cooperativity as the basis for the Frank-Starling Law",

abstract = "Combining Hill's statistical-mechanical model of thin-filament cooperativity with an attachment equilibrium dependent on radial spacing yields forcepCa relations that become more sensitive to calcium as attachment becomes more favorable (when radial spacing shrinks toward optimum as sarcomeres lengthen). In a rat skinned trabecula, we measured force-pCa relations while varying radial spacing osmotically. Observations agreed with a unique prediction of this model: 'over' compression (beyond optimum) shifts forcepCa rightward.",

author = "William Hunter and Yiming Wu and Kenneth Campbell",

year = "2000",

language = "English (US)",

volume = "28",

pages = "S--60",

journal = "Annals of Biomedical Engineering",

issn = "0090-6964",

publisher = "Springer Netherlands",

number = "SUPPL. 1",

note = "2000 Annual Fall Meeting of the Biomedical Engineering Society ; Conference date: 12-10-2000 Through 14-10-2000",

}

TY - JOUR

T1 - Radial crossbridge elasticity coupled with thin-filament cooperativity as the basis for the Frank-Starling Law

AU - Hunter, William

AU - Wu, Yiming

AU - Campbell, Kenneth

PY - 2000

Y1 - 2000

N2 - Combining Hill's statistical-mechanical model of thin-filament cooperativity with an attachment equilibrium dependent on radial spacing yields forcepCa relations that become more sensitive to calcium as attachment becomes more favorable (when radial spacing shrinks toward optimum as sarcomeres lengthen). In a rat skinned trabecula, we measured force-pCa relations while varying radial spacing osmotically. Observations agreed with a unique prediction of this model: 'over' compression (beyond optimum) shifts forcepCa rightward.

AB - Combining Hill's statistical-mechanical model of thin-filament cooperativity with an attachment equilibrium dependent on radial spacing yields forcepCa relations that become more sensitive to calcium as attachment becomes more favorable (when radial spacing shrinks toward optimum as sarcomeres lengthen). In a rat skinned trabecula, we measured force-pCa relations while varying radial spacing osmotically. Observations agreed with a unique prediction of this model: 'over' compression (beyond optimum) shifts forcepCa rightward.

UR - http://www.scopus.com/inward/record.url?scp=0034506108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034506108&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0034506108

SN - 0090-6964

VL - 28

SP - S-60

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - SUPPL. 1

T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society

Y2 - 12 October 2000 through 14 October 2000

ER -

Radial crossbridge elasticity coupled with thin-filament cooperativity as the basis for the Frank-Starling Law

Abstract

All Science Journal Classification (ASJC) codes

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