Radial crossbridge elasticity coupled with thin-filament cooperativity as the basis for the Frank-Starling Law

William Hunter, Yiming Wu, Kenneth Campbell

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

Combining Hill's statistical-mechanical model of thin-filament cooperativity with an attachment equilibrium dependent on radial spacing yields forcepCa relations that become more sensitive to calcium as attachment becomes more favorable (when radial spacing shrinks toward optimum as sarcomeres lengthen). In a rat skinned trabecula, we measured force-pCa relations while varying radial spacing osmotically. Observations agreed with a unique prediction of this model: 'over' compression (beyond optimum) shifts forcepCa rightward.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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