Recent advancements in oxygen-releasing materials for tissue regenerative medicine and wound healing

Oxygen-releasing biomaterials have been used to resolve hypoxia-related challenges in tissue regeneration and wound healing process. This group of biomaterials has pratical challenges, such as oxidative stress, biocompatibility, and high manufacturing costs. This review focuses on the role of oxygen in cellular metabolism, angiogenesis, collagen production, and immune response for chronic and ischemic wounds. Typical oxygen-releasing biomaterials, including peroxide-based compounds (e.g., calcium- and magnesium-based), metal-organic frameworks (MOFs), hemoglobin-based oxygen carriers (HBOCs), perfluorocarbons (PFCs), zeolites, and cyclodextrin-based nanosponges are described and discussed. Other mechanisms, such as hydrolysis, enzymatic activity, and stimuli-responsive release are reviewed, highlighting their applications in tissue regeneration and chronic wound care. Current challenges are also presented, along with an outline of future directions to the development of next-generation oxygen-releasing biomaterials for clinical translation.