TY - JOUR
T1 - Recovery of resting brain connectivity ensuing mild traumatic brain injury
AU - Bharath, Rose D.
AU - Munivenkatappa, Ashok
AU - Gohel, Suril
AU - Panda, Rajanikant
AU - Saini, Jitender
AU - Rajeswaran, Jamuna
AU - Shukla, Dhaval
AU - Bhagavatula, Indira D.
AU - Biswal, Bharat B.
N1 - Publisher Copyright:
© 2015 Bharath, Munivenkatappa, Gohel, Panda, Saini, Rajeswaran, Shukla,Bhagavatula and Biswal.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/9/22
Y1 - 2015/9/22
N2 - Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.
AB - Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.
KW - Brain plasticity
KW - Hyper connectivity
KW - Longitudinal study
KW - Mild traumatic brain injury
KW - Resting state functional connectivity
KW - Time varying changes
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U2 - 10.3389/fnhum.2015.00513
DO - 10.3389/fnhum.2015.00513
M3 - Article
AN - SCOPUS:84942924740
VL - 9
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
SN - 1662-5161
IS - September
M1 - 513
ER -