Reverse engineering regulatory networks in cells using a dynamic Bayesian network and mutual information scoring function

Haodi Jiang, Turki Turki, Jason T.L. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In systems biology, two important regulatory networks are gene regulatory networks (GRNs) and regulatory networks of microRNAs (RNMs). A GRN is modeled as a directed graph in which a node represents a gene or transcription factor (TF), and an edge from a TF to a gene indicates that the TF regulates the expression of the gene. An RNM is modeled as a bipartite directed graph with two disjoint sets of nodes: A set of nodes that represent microRNAs (miRNAs) and a set of nodes that represent genes or TFs. Directed edges between these two sets of nodes represent miRNA-target interactions or TF-miRNA regulatory relations. In this paper, we present an approach to reverse engineering GRNs and RNMs using a dynamic Bayesian network and mutual information scoring function. Our approach is able to automatically infer both GRNs and RNMs from time series of expression data. Experimental results on different datasets show that our approach is more accurate than other time-series based network inference methods.

Original languageEnglish (US)
Title of host publicationProceedings - 16th IEEE International Conference on Machine Learning and Applications, ICMLA 2017
EditorsXuewen Chen, Bo Luo, Feng Luo, Vasile Palade, M. Arif Wani
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages761-764
Number of pages4
ISBN (Electronic)9781538614174
DOIs
StatePublished - Jan 1 2017
Event16th IEEE International Conference on Machine Learning and Applications, ICMLA 2017 - Cancun, Mexico
Duration: Dec 18 2017Dec 21 2017

Publication series

NameProceedings - 16th IEEE International Conference on Machine Learning and Applications, ICMLA 2017
Volume2017-December

Other

Other16th IEEE International Conference on Machine Learning and Applications, ICMLA 2017
CountryMexico
CityCancun
Period12/18/1712/21/17

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Computer Science Applications

Keywords

  • Bayesian networks
  • data mining
  • machine learning
  • mutual information
  • systems biology

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