TY - JOUR
T1 - Review of current literature for vascularized biomaterials in dental repair
AU - Moghanian, Amirhossein
AU - Cecen, Berivan
AU - Nafisi, Nazanin
AU - Miri, Zahra
AU - Rosenzweig, Derek H.
AU - Miri, Amir K.
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/11
Y1 - 2022/11
N2 - Recent dental repair strategies involve various bioactive materials, from synthetic polymeric implants and natural polymers to bioceramics and engineered self-assembling peptides. Chemosynthetic and tissue-mimetic scaffolds offer good biophysical tunability, such as flexible strength, and biological triggering molecules, such as angiogenic factors. They induce tissue growth and vascularization in the dental complex. This review summarizes the advantages and issues with current dental biomaterials via their chemical composition, manufacturing challenges, and vascularization capacity. We then discuss the use of modern manufacturing to deliver of biomaterials into the dental complex. This review provides a roadmap for selecting appropriate strategies for injectable dental biomaterials.
AB - Recent dental repair strategies involve various bioactive materials, from synthetic polymeric implants and natural polymers to bioceramics and engineered self-assembling peptides. Chemosynthetic and tissue-mimetic scaffolds offer good biophysical tunability, such as flexible strength, and biological triggering molecules, such as angiogenic factors. They induce tissue growth and vascularization in the dental complex. This review summarizes the advantages and issues with current dental biomaterials via their chemical composition, manufacturing challenges, and vascularization capacity. We then discuss the use of modern manufacturing to deliver of biomaterials into the dental complex. This review provides a roadmap for selecting appropriate strategies for injectable dental biomaterials.
KW - Angiogenesis
KW - Hydrogels
KW - In-situ delivery
KW - Polypeptide
KW - Synthetic biology
UR - http://www.scopus.com/inward/record.url?scp=85135340279&partnerID=8YFLogxK
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U2 - 10.1016/j.bej.2022.108545
DO - 10.1016/j.bej.2022.108545
M3 - Article
AN - SCOPUS:85135340279
SN - 1369-703X
VL - 187
JO - Biochemical Engineering Journal
JF - Biochemical Engineering Journal
M1 - 108545
ER -