Review of current literature for vascularized biomaterials in dental repair

Amirhossein Moghanian; Berivan Cecen; Nazanin Nafisi; Zahra Miri; Derek H. Rosenzweig; Amir K. Miri

doi:10.1016/j.bej.2022.108545

Review of current literature for vascularized biomaterials in dental repair

Amirhossein Moghanian, Berivan Cecen, Nazanin Nafisi, Zahra Miri, Derek H. Rosenzweig, Amir K. Miri

Bio-Medical Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Recent dental repair strategies involve various bioactive materials, from synthetic polymeric implants and natural polymers to bioceramics and engineered self-assembling peptides. Chemosynthetic and tissue-mimetic scaffolds offer good biophysical tunability, such as flexible strength, and biological triggering molecules, such as angiogenic factors. They induce tissue growth and vascularization in the dental complex. This review summarizes the advantages and issues with current dental biomaterials via their chemical composition, manufacturing challenges, and vascularization capacity. We then discuss the use of modern manufacturing to deliver of biomaterials into the dental complex. This review provides a roadmap for selecting appropriate strategies for injectable dental biomaterials.

Original language	English (US)
Article number	108545
Journal	Biochemical Engineering Journal
Volume	187
DOIs	https://doi.org/10.1016/j.bej.2022.108545
State	Published - Nov 2022

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Environmental Engineering
Biomedical Engineering

Keywords

Angiogenesis
Hydrogels
In-situ delivery
Polypeptide
Synthetic biology

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10.1016/j.bej.2022.108545

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title = "Review of current literature for vascularized biomaterials in dental repair",

abstract = "Recent dental repair strategies involve various bioactive materials, from synthetic polymeric implants and natural polymers to bioceramics and engineered self-assembling peptides. Chemosynthetic and tissue-mimetic scaffolds offer good biophysical tunability, such as flexible strength, and biological triggering molecules, such as angiogenic factors. They induce tissue growth and vascularization in the dental complex. This review summarizes the advantages and issues with current dental biomaterials via their chemical composition, manufacturing challenges, and vascularization capacity. We then discuss the use of modern manufacturing to deliver of biomaterials into the dental complex. This review provides a roadmap for selecting appropriate strategies for injectable dental biomaterials.",

keywords = "Angiogenesis, Hydrogels, In-situ delivery, Polypeptide, Synthetic biology",

author = "Amirhossein Moghanian and Berivan Cecen and Nazanin Nafisi and Zahra Miri and Rosenzweig, {Derek H.} and Miri, {Amir K.}",

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AU - Moghanian, Amirhossein

AU - Cecen, Berivan

AU - Nafisi, Nazanin

AU - Miri, Zahra

AU - Rosenzweig, Derek H.

AU - Miri, Amir K.

PY - 2022/11

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AB - Recent dental repair strategies involve various bioactive materials, from synthetic polymeric implants and natural polymers to bioceramics and engineered self-assembling peptides. Chemosynthetic and tissue-mimetic scaffolds offer good biophysical tunability, such as flexible strength, and biological triggering molecules, such as angiogenic factors. They induce tissue growth and vascularization in the dental complex. This review summarizes the advantages and issues with current dental biomaterials via their chemical composition, manufacturing challenges, and vascularization capacity. We then discuss the use of modern manufacturing to deliver of biomaterials into the dental complex. This review provides a roadmap for selecting appropriate strategies for injectable dental biomaterials.

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KW - Hydrogels

KW - In-situ delivery

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Review of current literature for vascularized biomaterials in dental repair

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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