Review of current literature for vascularized biomaterials in dental repair

Amirhossein Moghanian, Berivan Cecen, Nazanin Nafisi, Zahra Miri, Derek H. Rosenzweig, Amir K. Miri

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Recent dental repair strategies involve various bioactive materials, from synthetic polymeric implants and natural polymers to bioceramics and engineered self-assembling peptides. Chemosynthetic and tissue-mimetic scaffolds offer good biophysical tunability, such as flexible strength, and biological triggering molecules, such as angiogenic factors. They induce tissue growth and vascularization in the dental complex. This review summarizes the advantages and issues with current dental biomaterials via their chemical composition, manufacturing challenges, and vascularization capacity. We then discuss the use of modern manufacturing to deliver of biomaterials into the dental complex. This review provides a roadmap for selecting appropriate strategies for injectable dental biomaterials.

Original languageEnglish (US)
Article number108545
JournalBiochemical Engineering Journal
StatePublished - Nov 2022

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Environmental Engineering
  • Biomedical Engineering


  • Angiogenesis
  • Hydrogels
  • In-situ delivery
  • Polypeptide
  • Synthetic biology


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