Review of resting-state functional connectivity methods and application in clinical populations

Keerthana Karunakaran, Marie Wolfer, Bharat B. Biswal

Research output: Chapter in Book/Report/Conference proceedingChapter


Functional magnetic resonance imaging (fMRI) studies of the resting state have provided consistent and reliable brain networks defined by spatially distinct regions whose interactions are both functionally segregated and integrated across the whole brain. Functional connections integrate multiple brain systems to produce unique networks attending to the different cognitive and sensory demands of the body. Detection and quantification of functional connectivity has been fundamental to the investigation of behavioral and clinical abnormalities in brain function using noninvasive human neuroimaging. It has expanded our ability to examine the brain physiology and pathophysiology across different age groups and clinical populations. Several techniques exist in literature to identify and quantify the functional connectivity metrics of brain regions using resting-state fMRI. In this chapter, we review the neurophysiological basis of resting-state functional connectivity and give a synopsis of the most established resting-state analysis techniques. We also summarize relevant findings from an array of clinical populations including neuropsychological disorders to emphasize the versatility of resting-state fMRI.

Original languageEnglish (US)
Title of host publicationBrain Network Dysfunction in Neuropsychiatric Illness
Subtitle of host publicationMethods, Applications, and Implications
Number of pages30
ISBN (Electronic)9783030597979
ISBN (Print)9783030597962
StatePublished - May 11 2021

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Neuroscience


  • Aging
  • Brain connectivity
  • Brain function
  • FMRI
  • Neuropsychiatry
  • Resting state


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