Rheological study and characterization of acetaminophen and poly (ethylene) oxide for hot-melt extrusion process

Herman Suwardie, Min Yang, Peng Wang, Huiju Liu, Costas G. Gogos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Solid dispersions made from mixing polymers and drug have caught a lot interest in recent years. One major technical barrier limiting broader applications of solid dispersions is the lack of drug's solubility data in polymer matrix. Furthermore, there is no standard or widely accepted method for the testing of drug's solubility. Zhang et. al [1] developed a novel method using Differential Scanning Calorimeter (DSC) recently. However, it requires tedious and delicate experimental work. Therefore, a new method via rheological characterization is explored in our laboratory. The steady (from both oscillatory and capillary rheometer) and dynamic (oscillatory rheometer) viscosities of the drug-polymer system are measured for different drug concentrations at various temperatures. The rheological results presented not only can be utilized for process optimization and material characterization, such as molecular weight determination, but also provides valuable information on the drug's solubility in polymeric excipients.

Original languageEnglish (US)
Title of host publication68th Annual Technical Conference of the Society of Plastics Engineers 2010, ANTEC 2010
Pages2184-2187
Number of pages4
StatePublished - Sep 27 2010
Event68th Annual Technical Conference of the Society of Plastics Engineers 2010, ANTEC 2010 - Orlando, FL, United States
Duration: May 16 2010May 20 2010

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume3

Other

Other68th Annual Technical Conference of the Society of Plastics Engineers 2010, ANTEC 2010
CountryUnited States
CityOrlando, FL
Period5/16/105/20/10

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

Keywords

  • Hot melt extrusion
  • Rheology
  • Solubility
  • Zero shear viscosity

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