Rodent model systems for studies of HIV-1 associated dementia

Yuri Persidsky, Raghava Potula, James Haorah

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Understanding of HIV-1 neuropathogenesis and development of rationale therapeutic approaches requires relevant animal models. The putative mechanisms of neuroinflammatory and neurotoxic events triggered by HIV-1 brain infection are reflected by a number of rodent models. These include transgenic animals (either expressing viral proteins or pro-inflammatory factors), infection with murine retroviruses, and severe combined immunodeficient (SCID) mice reconstituted with human lymphocytes and injected intracerebrally with HIV-1-infected human monocyte-derived macrophages. The potential importance and limitations of the models in reflecting human disease are discussed with emphasis on their utility for development of therapies to combat HIV-1-associated neurologic impairment.

Original languageEnglish (US)
Pages (from-to)91-106
Number of pages16
JournalNeurotoxicity Research
Volume8
Issue number1-2
DOIs
StatePublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Toxicology

Keywords

  • Dementia
  • HAD
  • HIV-1
  • Neuroinflammation
  • Neuropathogenesis
  • Rodent model
  • Severe combined Immunodeficient

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