Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers

Cristiano L. Dias, Sharareh Jalali, Yanxing Yang, Luis Cruz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Molecular dynamics simulations are used to provide insights into the molecular mechanisms accounting for binding of amyloid fibrils to lipid bilayers and to study the effect of cholesterol in this process. We show that electrostatic interactions play an important role in fibril-bilayer binding and cholesterol modulates this interaction. In particular, the interaction between positive residues and lipid head groups becomes more favorable in the presence of cholesterol. Consistent with experiments, we find that cholesterol enhances fibril-membrane binding.

Original languageEnglish (US)
Pages (from-to)3036-3042
Number of pages7
JournalJournal of Physical Chemistry B
Volume124
Issue number15
DOIs
StatePublished - Apr 16 2020

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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