Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

Daiyong Deng, Riya Patel, Cheng Yao Chiang, Pingping Hou

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the importance of exploiting cells in the tumor microenvironment to thwart cancers. In this review, we summarize the hallmarks of the multifaceted pancreatic tumor microenvironment, notably pancreatic stellate cells, tumor-associated fibroblasts, macrophages, and neutrophils, in the regulation of chemo-, radio-, immuno-, and targeted therapy resistance in pancreatic cancer. The molecular insight will facilitate the development of novel therapeutics against pancreatic cancer.

Original languageEnglish (US)
Article number2952
Issue number19
StatePublished - Oct 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


  • pancreatic cancer
  • therapy resistance
  • tumor microenvironment


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