Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

Daiyong Deng; Riya Patel; Cheng Yao Chiang; Pingping Hou

doi:10.3390/cells11192952

Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

Daiyong Deng, Riya Patel, Cheng Yao Chiang, Pingping Hou

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the importance of exploiting cells in the tumor microenvironment to thwart cancers. In this review, we summarize the hallmarks of the multifaceted pancreatic tumor microenvironment, notably pancreatic stellate cells, tumor-associated fibroblasts, macrophages, and neutrophils, in the regulation of chemo-, radio-, immuno-, and targeted therapy resistance in pancreatic cancer. The molecular insight will facilitate the development of novel therapeutics against pancreatic cancer.

Original language	English (US)
Article number	2952
Journal	Cells
Volume	11
Issue number	19
DOIs	https://doi.org/10.3390/cells11192952
State	Published - Oct 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

Keywords

pancreatic cancer
therapy resistance
tumor microenvironment

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10.3390/cells11192952

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title = "Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance",

abstract = "Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the importance of exploiting cells in the tumor microenvironment to thwart cancers. In this review, we summarize the hallmarks of the multifaceted pancreatic tumor microenvironment, notably pancreatic stellate cells, tumor-associated fibroblasts, macrophages, and neutrophils, in the regulation of chemo-, radio-, immuno-, and targeted therapy resistance in pancreatic cancer. The molecular insight will facilitate the development of novel therapeutics against pancreatic cancer.",

keywords = "pancreatic cancer, therapy resistance, tumor microenvironment",

author = "Daiyong Deng and Riya Patel and Chiang, {Cheng Yao} and Pingping Hou",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

doi = "10.3390/cells11192952",

language = "English (US)",

volume = "11",

journal = "Cells",

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T1 - Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

AU - Deng, Daiyong

AU - Patel, Riya

AU - Chiang, Cheng Yao

AU - Hou, Pingping

PY - 2022/10

Y1 - 2022/10

N2 - Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the importance of exploiting cells in the tumor microenvironment to thwart cancers. In this review, we summarize the hallmarks of the multifaceted pancreatic tumor microenvironment, notably pancreatic stellate cells, tumor-associated fibroblasts, macrophages, and neutrophils, in the regulation of chemo-, radio-, immuno-, and targeted therapy resistance in pancreatic cancer. The molecular insight will facilitate the development of novel therapeutics against pancreatic cancer.

AB - Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the importance of exploiting cells in the tumor microenvironment to thwart cancers. In this review, we summarize the hallmarks of the multifaceted pancreatic tumor microenvironment, notably pancreatic stellate cells, tumor-associated fibroblasts, macrophages, and neutrophils, in the regulation of chemo-, radio-, immuno-, and targeted therapy resistance in pancreatic cancer. The molecular insight will facilitate the development of novel therapeutics against pancreatic cancer.

KW - pancreatic cancer

KW - therapy resistance

KW - tumor microenvironment

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U2 - 10.3390/cells11192952

DO - 10.3390/cells11192952

M3 - Review article

C2 - 36230914

AN - SCOPUS:85139778405

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

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M1 - 2952

ER -

Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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