Scaling in force spectroscopy of macromolecules

Cristiano L. Dias; Martin Dubé; Fernando A. Oliveira; Martin Grant

doi:10.1103/PhysRevE.72.011918

Scaling in force spectroscopy of macromolecules

Cristiano L. Dias, Martin Dubé, Fernando A. Oliveira, Martin Grant

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We use molecular dynamics to determine the force needed to rupture a chain molecule being stretched at constant loading rate and temperature. When all energy bonds of the molecule are identical, we find that the force F depends on the pulling rate r and temperature T according to F∼const-T13ln(rT)13. When a single weak bond is introduced, this result is modified to F∼const-T23ln(rT)23. This scaling, which is model independent, can be used with experiment to quantitatively extract relevant microscopic parameters.

Original language	English (US)
Article number	011918
Journal	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume	72
Issue number	1
DOIs	https://doi.org/10.1103/PhysRevE.72.011918
State	Published - Jul 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Statistical and Nonlinear Physics
Statistics and Probability
Condensed Matter Physics

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10.1103/PhysRevE.72.011918

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abstract = "We use molecular dynamics to determine the force needed to rupture a chain molecule being stretched at constant loading rate and temperature. When all energy bonds of the molecule are identical, we find that the force F depends on the pulling rate r and temperature T according to F∼const-T13ln(rT)13. When a single weak bond is introduced, this result is modified to F∼const-T23ln(rT)23. This scaling, which is model independent, can be used with experiment to quantitatively extract relevant microscopic parameters.",

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T1 - Scaling in force spectroscopy of macromolecules

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AU - Dubé, Martin

AU - Oliveira, Fernando A.

AU - Grant, Martin

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AB - We use molecular dynamics to determine the force needed to rupture a chain molecule being stretched at constant loading rate and temperature. When all energy bonds of the molecule are identical, we find that the force F depends on the pulling rate r and temperature T according to F∼const-T13ln(rT)13. When a single weak bond is introduced, this result is modified to F∼const-T23ln(rT)23. This scaling, which is model independent, can be used with experiment to quantitatively extract relevant microscopic parameters.

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Scaling in force spectroscopy of macromolecules

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