Selection of natural biomaterials for micro-tissue and organ-on-chip models

Berivan Cecen, Ayca Bal-Ozturk, Gokcen Yasayan, Emine Alarcin, Polen Kocak, Rumeysa Tutar, Leyla Didem Kozaci, Su Ryon Shin, Amir K. Miri

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The desired organ in micro-tissue models of organ-on-a-chip (OoC) devices dictates the optimum biomaterials, divided into natural and synthetic biomaterials. They can resemble biological tissues' biological functions and architectures by constructing bioactivity of macromolecules, cells, nanoparticles, and other biological agents. The inclusion of such components in OoCs allows them having biological processes, such as basic biorecognition, enzymatic cleavage, and regulated drug release. In this report, we review natural-based biomaterials that are used in OoCs and their main characteristics. We address the preparation, modification, and characterization methods of natural-based biomaterials and summarize recent reports on their applications in the design and fabrication of micro-tissue models. This article will help bioengineers select the proper biomaterials based on developing new technologies to meet clinical expectations and improve patient outcomes fusing disease modeling.

Original languageEnglish (US)
Pages (from-to)1147-1165
Number of pages19
JournalJournal of Biomedical Materials Research - Part A
Issue number5
StatePublished - May 2022

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys


  • hydrogels
  • micro-tissue
  • natural biopolymers
  • organ-on-a-chip


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