Selective stimulation of the canine hypoglossal nerve using a multi-contact cuff electrode

Paul B. Yoo, Mesut Sahin, Dominique M. Durand

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Electrical activation of the tongue protrusor muscle has been demonstrated as an effective technique for alleviating upper airway (UAW) obstructions and is considered a potential treatment for obstructive sleep apnea (OSA). Recent studies, however, have shown marked improvements in UAW patency by coactivating the tongue protrudor and retractor muscles. As such, selective stimulation of the hypoglossal nerve (XII) using a single implantable device presents an attractive approach for treating OSA. In order to demonstrate the feasibility of such a device, the maximum achievable stimulation selectivity of the Flat Interface Nerve Electrode (FINE) was investigated. The XII nerve of beagles was stimulated with an acutely implanted FINE, while the corresponding neural and muscular responses were recorded and analyzed. The overall performance of the FINE, as depicted by the average of the maximum target-specific selectivity values, S(i), confirmed that high degrees of selectivity can be achieved at both the fascicular and muscular levels: 0.93 ± 0.03 (n = 5) and 0.88 ± 0.03 (n = 4), respectively. The results of this study demonstrate the feasibility of the FINE for selective stimulation of the XII nerve branches and the innervated tongue muscles.

Original languageEnglish (US)
Pages (from-to)511-519
Number of pages9
JournalAnnals of Biomedical Engineering
Volume32
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Keywords

  • Compound action potential
  • Electromyogram
  • Flat interface nerve electrode
  • Obstructive sleep apnea
  • Selective nerve stimulation

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