Selective stimulation of the hypoglossal nerve: A fine approach to treating obstructive sleep apnea

P. B. Yoo, M. Sahin, D. M. Durand

Research output: Contribution to journalConference articlepeer-review

6 Scopus citations


Isolated activation of the tongue protrusor muscles is the current technique for treating obstructive sleep apnea (OSA) via functional electrical stimulation. Recent studies, however, have shown marked improvements in upper airway (UAW) patency by co-activating the tongue protrudor and retractor muscles. As such, selective stimulation of the hypoglossal (XII) nerve with a single implantable device presents an attractive alternative for treating OSA. In order to demonstrate the feasibility of such a device, the maximum achievable stimulation selectivity of the Flat Interface Nerve Electrode (FINE) was investigated. The beagle XII nerve was stimulated with an implanted FINE, while the corresponding neural and muscular responses were recorded. The overall performance of the FINE, as defined by the selectivity index (SI), showed a high degree of selectivity at both the fascicular and muscular levels: 0.91 ± 0.05 (n = 5) and 0.85 ± 0.03 (n = 4), respectively. The results clearly demonstrate the feasibility of the FINE for selective stimulation of the XII nerve and UAW muscles.

Original languageEnglish (US)
Pages (from-to)2049-2050
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - 2002
Externally publishedYes
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Health Informatics
  • Computer Vision and Pattern Recognition
  • Biomedical Engineering


  • Electromyogram
  • Electroneurogram
  • Hypoglossal nerve
  • Obstructive sleep apnea
  • Selective stimulation


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