Self-Assembling Peptides with Insulin-Like Growth Factor Mimicry

Abhishek Roy, Joseph B. Dodd-O, Alicia S. Robang, Dongjing He, Owen West, Zain Siddiqui, Erika Davidoff Aguas, Hannah Goldberg, Alexandra Griffith, Corey Heffernan, Yuhang Hu, Anant K. Paravastu, Vivek A. Kumar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Growth factor (GF) mimicry involves recapitulating the signaling of larger molecules or cells. Although GF mimicry holds considerable promise in tissue engineering and drug design applications, difficulties in targeting the signaling molecule to the site of delivery and dissociation of mimicking peptides from their target receptors continue to limit its clinical application. To address these challenges, we utilized a self-assembling peptide (SAP) platform to generate synthetic insulin-like growth factor (IGF)-signaling, self-assembling GFs. Our peptide hydrogels are biocompatible and bind target IGF receptors in a dose-dependent fashion, activate proangiogenic signaling, and facilitate formation of angiogenic microtubules in vitro. Furthermore, infiltrated hydrogels are stable for weeks to months. We conclude that the enhanced targeting and long-term stability of our SAP/GF mimicry implants may improve the efficacy and safety of future GF mimic therapeutics.

Original languageEnglish (US)
Pages (from-to)364-375
Number of pages12
JournalACS Applied Materials and Interfaces
Issue number1
StatePublished - Jan 10 2024

All Science Journal Classification (ASJC) codes

  • General Materials Science


  • growth factor mimicry
  • insulin-like growth factor
  • receptor binding
  • self-assembly
  • tissue engineering


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