TY - JOUR
T1 - Sensorimotor cortex reorganization in subacute and chronic stroke
T2 - A neuronavigated TMS study
AU - Yarossi, Mathew
AU - Adamovich, Sergei
AU - Tunik, Eugene
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The integrity of the corticospinal system is an important biomarker for recovery from stroke. However, mapping the topography of the corticospinal system in subacute stroke is not trivial and how it changes over the course of recovery is poorly understood. We intend to use a transcranial magnetic stimulation (TMS) based mapping approach to quantify the topographic landscape of corticospinal activation in the ipsi- and contralesional sensorimotor cortices in the subacute and chronic phase of stroke. Mapping was conducted before (PRE) and after (POST), intervention in 10 chronic subjects and 8 subacute subjects. Reorganization was quantified in a unique way by dissociating reorganization attributed to changes in the expanse (area) of the sensorimotor territory, from that attributed to changes in the robustness of the activation (amplitude). In doing so, we observed differences in reorganization in the subacute and chronic stages indicating that recovery in different stages may not be guided by similar neurophysiological mechanisms of neuroplasticity.
AB - The integrity of the corticospinal system is an important biomarker for recovery from stroke. However, mapping the topography of the corticospinal system in subacute stroke is not trivial and how it changes over the course of recovery is poorly understood. We intend to use a transcranial magnetic stimulation (TMS) based mapping approach to quantify the topographic landscape of corticospinal activation in the ipsi- and contralesional sensorimotor cortices in the subacute and chronic phase of stroke. Mapping was conducted before (PRE) and after (POST), intervention in 10 chronic subjects and 8 subacute subjects. Reorganization was quantified in a unique way by dissociating reorganization attributed to changes in the expanse (area) of the sensorimotor territory, from that attributed to changes in the robustness of the activation (amplitude). In doing so, we observed differences in reorganization in the subacute and chronic stages indicating that recovery in different stages may not be guided by similar neurophysiological mechanisms of neuroplasticity.
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U2 - 10.1109/EMBC.2014.6944943
DO - 10.1109/EMBC.2014.6944943
M3 - Article
C2 - 25571311
SN - 1557-170X
VL - 2014
SP - 5788
EP - 5791
JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
ER -