Sensorimotor cortex reorganization in subacute and chronic stroke: A neuronavigated TMS study

Mathew Yarossi, Sergei Adamovich, Eugene Tunik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

The integrity of the corticospinal system is an important biomarker for recovery from stroke. However, mapping the topography of the corticospinal system in subacute stroke is not trivial and how it changes over the course of recovery is poorly understood. We intend to use a transcranial magnetic stimulation (TMS) based mapping approach to quantify the topographic landscape of corticospinal activation in the ipsi- and contralesional sensorimotor cortices in the subacute and chronic phase of stroke. Mapping was conducted before (PRE) and after (POST), intervention in 10 chronic subjects and 8 subacute subjects. Reorganization was quantified in a unique way by dissociating reorganization attributed to changes in the expanse (area) of the sensorimotor territory, from that attributed to changes in the robustness of the activation (amplitude). In doing so, we observed differences in reorganization in the subacute and chronic stages indicating that recovery in different stages may not be guided by similar neurophysiological mechanisms of neuroplasticity.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5788-5791
Number of pages4
ISBN (Electronic)9781424479290
DOIs
StatePublished - Nov 2 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Publication series

Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/TerritoryUnited States
CityChicago
Period8/26/148/30/14

All Science Journal Classification (ASJC) codes

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering
  • Medicine(all)

Keywords

  • brain reorganization
  • hand rehabilitation
  • stroke
  • transcranial magnetic stimulation

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