TY - JOUR
T1 - Sensorimotor Transformations in the Zebrafish Auditory System
AU - Privat, Martin
AU - Romano, Sebastián A.
AU - Pietri, Thomas
AU - Jouary, Adrien
AU - Boulanger-Weill, Jonathan
AU - Elbaz, Nicolas
AU - Duchemin, Auriane
AU - Soares, Daphne
AU - Sumbre, Germán
N1 - Funding Information:
We thank V. Candat and F. Bouallague for help with zebrafish, A. Kulkarni for discussions on data analysis, and O. Lahrach and Anahid Jeant-Maloumian for preliminary experiments. M.P. was supported by the Fondation pour la Recherche Medicale ( FRM: FDT201904008327 ) and the ENS Lyon . A.J. was supported by the Fondation pour la Recherche Medicale ( FRM: FDT20140930915 ) and the ENS Cachan . A.D. was supported by the ENS Cachan , and G.S. was supported by ERC StG 243106 , ERC CoG 726280 , ANR-10-LABX-54 MEMO LIFE , and ANR-11-IDEX-0001-02 PSL Research University . D.S. was supported by the Ecole Normale Supérieure invited professor program and NIH R15EY027112 .
Funding Information:
We thank V. Candat and F. Bouallague for help with zebrafish, A. Kulkarni for discussions on data analysis, and O. Lahrach and Anahid Jeant-Maloumian for preliminary experiments. M.P. was supported by the Fondation pour la Recherche Medicale (FRM: FDT201904008327) and the ENS Lyon. A.J. was supported by the Fondation pour la Recherche Medicale (FRM: FDT20140930915) and the ENS Cachan. A.D. was supported by the ENS Cachan, and G.S. was supported by ERC StG 243106, ERC CoG 726280, ANR-10-LABX-54 MEMO LIFE, and ANR-11-IDEX-0001-02 PSL Research University. D.S. was supported by the Ecole Normale Sup?rieure invited professor program and NIH R15EY027112. G.S. and M.P. designed and conducted the experiments. S.A.R. T.P. A.D. N.E. and D.S. performed preliminary experiments. M.P. analyzed the data. M.P. D.S. and G.S. wrote the manuscript. S.A.R. J.B.-W. A.J. and T.P. provided help for the data analysis and experimental design. The authors declare no competing interests.
Publisher Copyright:
© 2019 The Author(s)
PY - 2019/12/2
Y1 - 2019/12/2
N2 - Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.
AB - Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.
KW - audition
KW - behavior
KW - neuronal circuit dynamics
KW - sensorimotor transformations
KW - two-photon calcium imaging
KW - zebrafish larva
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U2 - 10.1016/j.cub.2019.10.020
DO - 10.1016/j.cub.2019.10.020
M3 - Article
C2 - 31708392
AN - SCOPUS:85075370316
SN - 0960-9822
VL - 29
SP - 4010-4023.e4
JO - Current Biology
JF - Current Biology
IS - 23
ER -