Shape-based reconstruction from nevoscope optical images of skin lesions

Optical imaging of skin lesions has been of significant interest for early diagnosis and characterization of skin cancers. The work presented in this chapter is in continuation of the development of an optical imaging based portable system with computerized analysis to detect skin cancers, particularly melanomas in early curable stage. The method developed in this paper can provide reconstructions of melanin and blood contents associated with a skin lesion fromits multispectral transillumination based optical images. The results of simulation of a skin lesion for reconstruction of melanin and blood (hemoglobin) information frommultispectral optical images are presented. Changes in melanin and hemoglobin contents in a skin lesion detected over time using the proposed method would allow early detection of malignant transformation and the development of a cancerous lesion.