Simplicity and complexity in the cyanobacterial circadian clock mechanism

Guogang Dong; Yong Ick Kim; Susan S. Golden

doi:10.1016/j.gde.2010.09.002

Simplicity and complexity in the cyanobacterial circadian clock mechanism

Guogang Dong, Yong Ick Kim, Susan S. Golden

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.

Original language	English (US)
Pages (from-to)	619-625
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/j.gde.2010.09.002
State	Published - Dec 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

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10.1016/j.gde.2010.09.002

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title = "Simplicity and complexity in the cyanobacterial circadian clock mechanism",

abstract = "The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.",

author = "Guogang Dong and Kim, {Yong Ick} and Golden, {Susan S.}",

note = "Funding Information: Our research is funded by grants from the National Institutes of Health ( R01 GM62419 , P01 NS39546 ) and the American Recovery and Reinvestment Act.",

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T1 - Simplicity and complexity in the cyanobacterial circadian clock mechanism

AU - Dong, Guogang

AU - Kim, Yong Ick

AU - Golden, Susan S.

N1 - Funding Information: Our research is funded by grants from the National Institutes of Health ( R01 GM62419 , P01 NS39546 ) and the American Recovery and Reinvestment Act.

PY - 2010/12

Y1 - 2010/12

N2 - The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.

AB - The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.

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JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

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Simplicity and complexity in the cyanobacterial circadian clock mechanism

Abstract

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