Simplicity and complexity in the cyanobacterial circadian clock mechanism

Guogang Dong, Yong Ick Kim, Susan S. Golden

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.

Original languageEnglish (US)
Pages (from-to)619-625
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number6
StatePublished - Dec 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


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