Simultaneous synthesis, stabilization, and self-assembly of microscale drug particles in polymer films

Xiangxin Meng, Dachuan Yang, Somenath Mitra

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The antisolvent synthesis of micrometer-scale particles, their stabilization in suspension, and their subsequent self-assembly as homogeneous polymer films suitable for drug delivery were studied. Ultrasonic agitation was used in the precipitation of the drug particulates, stabilization was carried out with hydroxypropyl methylcellulose (HPMC), and finally, drug-encapsulated films containing HPMC and polyvinylpyrrolidone were synthesized. These contained as much 28% of the drug Griseofulvin, and the particles were distributed uniformly throughout the films. Most importantly, the redispersion of the drug-loaded films in an aqueous matrix showed that the crystallinity remained unaltered, and there was no appreciable increase in the particle size distribution.

Original languageEnglish (US)
Pages (from-to)2082-2089
Number of pages8
JournalJournal of Applied Polymer Science
Volume120
Issue number4
DOIs
StatePublished - May 15 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

Keywords

  • drug delivery systems
  • films
  • nanotechnology
  • particle size distribution
  • stabilization

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