Slow vasomotor fluctuation in fMRI of anesthetized child brain

Vesa Kiviniemi, Jukka Jauhiainen, Osmo Tervonen, Eija Pääkkö, Jarkko Oikarinen, Vilho Vainionpää, Heikki Rantala, Bharat Biswal

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

Signal intensity changes in fMRI during rest caused by vasomotor fluctuations were investigated in this work. Resting-state baseline fluctuations were evaluated in 12 children anesthetized with thiopental. Five subjects had fluctuations related to subvoxel motion. In seven subjects without significant motion, slow signal fluctuation at 0.025-0.041 Hz near one or more primary sensory cortices was observed. In each subject the amplitude and frequency of the fluctuations were stable. It is hypothesized that thiopental, which reduces blood pressure and flow in the cortex, alters the feedback in neurovascular coupling leading to an increase in the magnitude and a reduction in the frequency of these fluctuations. The use of anesthesia in fMRI may provide new insight into neural connectivity and the coupling of blood flow and neural metabolism. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalMagnetic Resonance in Medicine
Volume44
Issue number3
DOIs
StatePublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Keywords

  • BOLD
  • Children
  • Functional connectivity
  • Thiopental
  • Vasomotor fluctuation
  • fMRI

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