Smart electrochemical biosensors: From advanced materials to ultrasensitive devices

Omowunmi A. Sadik, Samuel K. Mwilu, Austin Aluoch

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


The specificity, simplicity, and inherent miniaturization afforded by advances in modern electronics have allowed electrochemical sensors to rival the most advanced optical protocols. One major obstacle in implementing electrochemistry for studying biomolecular reaction is its inadequate sensitivity. Recent reports however showed unprecedented sensitivities for biomolecular recognition using enhanced electronic amplification provided by new classes of electrode materials (e.g. carbon nanotubes, metal nanoparticles, and quantum dots). Biosensor technology is one area where recent advances in nanomaterials are pushing the technological limits of electrochemical sensitivities, thus allowing for the development of new sensor chemistries and devices. This work focuses on our recent work, based on metal-enhanced electrochemical detection, and those of others in combining advanced nanomaterials with electrochemistry for the development of smart sensors for proteins, nucleic acids, drugs and cancer cells.

Original languageEnglish (US)
Pages (from-to)4287-4295
Number of pages9
JournalElectrochimica Acta
Issue number14
StatePublished - May 30 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemical Engineering
  • Electrochemistry


  • Electrochemistry
  • MED
  • Metal-enhanced detection
  • Nanostructured materials
  • Sensors


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