Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Raivo Uibo, Ivo Laidmäe, Evelyn S. Sawyer, Lisa A. Flanagan, Penelope C. Georges, Jessamine P. Winer, Paul A. Janmey

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Polymeric scaffolds formed from synthetic or natural materials have many applications in tissue engineering and medicine, and multiple material properties need to be optimized for specific applications. Recent studies have emphasized the importance of the scaffolds' mechanical properties to support specific cellular responses in addition to considerations of biochemical interactions, material transport, immunogenicity, and other factors that determine biocompatibility. Fibrin gels formed from purified fibrinogen and thrombin, the final two reactants in the blood coagulation cascade, have long been shown to be effective in wound healing and supporting the growth of cells in vitro and in vivo. Fibrin, even without additional growth factors or other components has potential for use in neuronal wound healing in part because of its mechanical compliance that supports the growth of neurons without activation of glial proliferation. This review summarizes issues related to the use of fibrin gels in neuronal cell contexts, with an emphasis on issues of immunogenicity, and considers the potential advantages and disadvantages of fibrin prepared from non-mammalian sources.

Original languageEnglish (US)
Pages (from-to)924-930
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1793
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • Fibrin
  • Immunogenic
  • Stiffness
  • Tissue engineering
  • Wound healing

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