Spectroscopic-speckle variance OCT for microvasculature detection and analysis

Xuan Liu, Kang Zhang, Yong Huang, Jin U. Kang

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

We propose and studied optical coherence tomography (OCT) combining spectroscopic (SOCT) and speckle variance (svOCT) functions to effectively detect locations of microvasculatures and assess blood oxygen saturation level. Chorioallantoic membrane of a chick embryo was imaged in vivo to perform the analysis of the system. We also studied the effect of speckle in spectral domain using experimental data and performed time-averaging to reduce speckle noise locally. We combined SOCT and svOCT images using hue, saturation and value (HSV) color map to show the localized spectroscopic property of blood. Results show distinct spectroscopic properties between arterial blood and capillary blood.

Original languageEnglish (US)
Pages (from-to)2995-3009
Number of pages15
JournalBiomedical Optics Express
Volume2
Issue number11
DOIs
StatePublished - 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Spectroscopic-speckle variance OCT for microvasculature detection and analysis'. Together they form a unique fingerprint.

Cite this