Spherical Caps in Cell Polarization

Rocky Diegmiller, Hadrien Montanelli, Cyrill B. Muratov, Stanislav Y. Shvartsman

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.

Original languageEnglish (US)
Pages (from-to)26-30
Number of pages5
JournalBiophysical Journal
Issue number1
StatePublished - Jul 3 2018

All Science Journal Classification (ASJC) codes

  • Biophysics


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