Spherical Caps in Cell Polarization

Rocky Diegmiller; Hadrien Montanelli; Cyrill B. Muratov; Stanislav Y. Shvartsman

doi:10.1016/j.bpj.2018.05.033

Spherical Caps in Cell Polarization

Rocky Diegmiller, Hadrien Montanelli, Cyrill B. Muratov, Stanislav Y. Shvartsman

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.

Original language	English (US)
Pages (from-to)	26-30
Number of pages	5
Journal	Biophysical Journal
Volume	115
Issue number	1
DOIs	https://doi.org/10.1016/j.bpj.2018.05.033
State	Published - Jul 3 2018

All Science Journal Classification (ASJC) codes

Biophysics

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10.1016/j.bpj.2018.05.033

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abstract = "Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.",

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AU - Montanelli, Hadrien

AU - Muratov, Cyrill B.

AU - Shvartsman, Stanislav Y.

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.

AB - Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.

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Spherical Caps in Cell Polarization

Abstract

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