@article{508d122ea1d2494a8a60f2f2f39f9033,
title = "Spherical Caps in Cell Polarization",
abstract = "Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.",
author = "Rocky Diegmiller and Hadrien Montanelli and Muratov, {Cyrill B.} and Shvartsman, {Stanislav Y.}",
note = "Funding Information: This work was supported by funding from the National Science Foundation Science and Technology Center for Emergent Behaviors of Integrated Cellular Systems ( CBET-0939511 ) and National Institutes of Health ( R01GM107103 ). This research was partially supported by the Allen Discovery Center program through The Paul G. Allen Frontiers Group . Funding Information: This work was supported by funding from the National Science Foundation Science and Technology Center for Emergent Behaviors of Integrated Cellular Systems (CBET-0939511) and National Institutes of Health (R01GM107103). This research was partially supported by the Allen Discovery Center program through The Paul G. Allen Frontiers Group. Publisher Copyright: {\textcopyright} 2018 Biophysical Society",
year = "2018",
month = jul,
day = "3",
doi = "10.1016/j.bpj.2018.05.033",
language = "English (US)",
volume = "115",
pages = "26--30",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Biophysical Society",
number = "1",
}