TY - GEN
T1 - Spontaneous autoresuscitation in a model of respiratory control
AU - Diekman, Casey O.
AU - Wilson, Christopher G.
AU - Thomas, Peter J.
PY - 2012
Y1 - 2012
N2 - We introduce a closed-loop model of respiratory control incorporating a conductance-based central pattern generator (CPG), low-pass filtering of CPG output by the respiratory musculature, gas exchange in the lung, metabolic oxygen demand, and chemosensation. The CPG incorporates Butera, Rinzel and Smith (BRS)'s (1999) conditional pacemaker model. BRS model cells can support quiescent, bursting, or beating activity depending on the level of excitatory drive; we identify these activity modes with apnea (cessation of breathing), eupnea (normal breathing), and tachypnea (excessively rapid breathing). We demonstrate the coexistence of two dynamically stable behaviors in the closed-loop model, corresponding respectively to eupnea and tachypnea. The latter state represents a novel failure mode within a respiratory control model. In addition, the closed-loop system exhibits a form of autoresuscitation: conductances intrinsic to the BRS model buffer the CPG against brief episodes of hypoxia, steering the system away from catastrophic collapse as can occur with tachypnea.
AB - We introduce a closed-loop model of respiratory control incorporating a conductance-based central pattern generator (CPG), low-pass filtering of CPG output by the respiratory musculature, gas exchange in the lung, metabolic oxygen demand, and chemosensation. The CPG incorporates Butera, Rinzel and Smith (BRS)'s (1999) conditional pacemaker model. BRS model cells can support quiescent, bursting, or beating activity depending on the level of excitatory drive; we identify these activity modes with apnea (cessation of breathing), eupnea (normal breathing), and tachypnea (excessively rapid breathing). We demonstrate the coexistence of two dynamically stable behaviors in the closed-loop model, corresponding respectively to eupnea and tachypnea. The latter state represents a novel failure mode within a respiratory control model. In addition, the closed-loop system exhibits a form of autoresuscitation: conductances intrinsic to the BRS model buffer the CPG against brief episodes of hypoxia, steering the system away from catastrophic collapse as can occur with tachypnea.
UR - http://www.scopus.com/inward/record.url?scp=84884192632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884192632&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2012.6347524
DO - 10.1109/EMBC.2012.6347524
M3 - Conference contribution
C2 - 23367459
AN - SCOPUS:84884192632
SN - 9781424441198
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 6669
EP - 6672
BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
T2 - 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
Y2 - 28 August 2012 through 1 September 2012
ER -