Abstract
"Chemical Equation Presented" A simple and effective method for stereocontrolled preparation of 1,1-diaryl-2-fluoroethenes is reported. First, 1-aryl-1-bromo-2-fluoroethenes are generated using an addition/elimination reaction of hydride to silylated, β,β-difluorostyrene derivatives followed by a bromination/desilicobromination reaction. Subsequent Suzuki-Miyaura coupling with a variety of boronic acids gives access to the desired 1,1-diaryl-2-fluoroethenes.
Original language | English (US) |
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Pages (from-to) | 5406-5409 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 11 |
Issue number | 23 |
DOIs | |
State | Published - Dec 3 2009 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry