Stereocontrolled access to unsymmetrical 1,1 -diaryl-2-fluoroethenes

Grégory Landelle, Marc Olivier Turcotte-Savard, Judikaëlle Marterer, Pier Alexandre Champagne, Jean François Paquin

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


"Chemical Equation Presented" A simple and effective method for stereocontrolled preparation of 1,1-diaryl-2-fluoroethenes is reported. First, 1-aryl-1-bromo-2-fluoroethenes are generated using an addition/elimination reaction of hydride to silylated, β,β-difluorostyrene derivatives followed by a bromination/desilicobromination reaction. Subsequent Suzuki-Miyaura coupling with a variety of boronic acids gives access to the desired 1,1-diaryl-2-fluoroethenes.

Original languageEnglish (US)
Pages (from-to)5406-5409
Number of pages4
JournalOrganic Letters
Issue number23
StatePublished - Dec 3 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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