Stereocontrolled approach to bromofluoroalkenes and their use for the synthesis of tri- and tetrasubstituted fluoroalkenes

Grégory Landelle, Pier Alexandre Champagne, Xavier Barbeau, Jean François Paquin

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

(Chemical Equation Presented) An addition/elimination reaction of organolithium reagents to silylated ββf-difluorostyrene derivatives followed by a bromination/ desilicobromination reaction provides a simple and effective synthetic approach to a wide range of bromofluoroalkenes (up to >97/3). In addition, the bromofluoroalkenes can be used in Pd-catalyzed transformations giving access to both tri- and tetrasubstituted fluoroalkenes.

Original languageEnglish (US)
Pages (from-to)681-684
Number of pages4
JournalOrganic Letters
Volume11
Issue number3
DOIs
StatePublished - Feb 5 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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