Strategy for Increasing Drug Solubility and Efficacy through Covalent Attachment to Polyvalent DNA-Nanoparticle Conjugates

Xue Qing Zhang, Xiaoyang Xu, Robert Lam, David Giljohann, Dean Ho, Chad A. Mirkina

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the study reported, Paclitaxel molecules are covalently attached to gold nanoparticles via fluorescent oligonucleotide linkers, resulting in a multimodal drug delivery system with simultaneous capabilities in imaging and enhanced therapy. The data suggest that these conjugates may solve three common problems associated with Paclitaxel as an effective chemotherapeutic agent. First, they enhance the solubility of the drug in aqueous systems such as buffers containing high concentrations of salts and serum-containing cell culture media. Second, they increase drug efficacy in Paclitaxel-resistant cell lines. Third, they provide a useful way of tracking the movement of the conjugates and delivery of the drug. An effective chemical strategy is developed for delivering hydrophobic Paclitaxel while simultaneously overcoming drug efflux in human cancer cells. Covalently attaching hydrophobic Paclitaxel onto gold nanoparticles via a DNA spacer resulted in significantly enhanced hydrophilicity and stability as compared to free Paclitaxel alone.

Original languageEnglish (US)
Title of host publicationSpherical Nucleic Acids
Subtitle of host publicationVolume 1
PublisherJenny Stanford Publishing
Pages451-473
Number of pages23
Volume1
ISBN (Electronic)9781000092356
ISBN (Print)9789814877213
DOIs
StatePublished - Jan 1 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering
  • General Chemistry

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