Structural and functional connectivity mapping of the human corpus callosum organization with white-matter functional networks

Pan Wang, Jianlin Wang, Qin Tang, Tara L. Alvarez, Zedong Wang, Yi Chia Kung, Ching Po Lin, Huafu Chen, Chun Meng, Bharat B. Biswal

Research output: Contribution to journalArticlepeer-review

Abstract

The corpus callosum serves as a crucial organization for understanding the information integration between the two hemispheres. Our previous study explored the functional connectivity between the corpus callosum and white-matter functional networks (WM-FNs), but the corresponding physical connectivity remains unknown. The current study uses the resting-state fMRI of Human Connectome Project data to identify ten WM-FNs in 108 healthy subjects, and then independently maps the structural and functional connectivity between the corpus callosum and above WM-FNs using the diffusion tensor images (DTI) tractography and resting-state functional connectivity (RSFC). Our results demonstrated that the structural and functional connectivity between the human corpus callosum and WM-FNs have the following high overall correspondence: orbitofrontal WM-FN, DTI map = 89% and RSFC map = 92%; sensorimotor middle WM-FN, DTI map = 47% and RSFC map = 77%; deep WM-FN, DTI map = 50% and RSFC map = 79%; posterior corona radiata WM-FN, DTI map = 82% and RSFC map = 73%. These findings reinforce the notion that the corpus callosum has unique spatial distribution patterns connecting to distinct WM-FNs. However, important differences between the structural and functional connectivity mapping results were also observed, which demonstrated a synergy between DTI tractography and RSFC toward better understanding the information integration of primary and higher-order functional systems in the human brain.

Original languageEnglish (US)
Article number117642
JournalNeuroImage
Volume227
DOIs
StatePublished - Feb 15 2021

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Keywords

  • Corpus callosum
  • DTI
  • Human Connectome project
  • Resting-state functional connectivity
  • White-matter functional networks

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