Structural-functional connectivity mapping of the insular cortex: A combined data-driven and meta-Analytic topic mapping

Benjamin Klugah-Brown, Pan Wang, Yuan Jiang, Benjamin Becker, Peng Hu, Lucina Q. Uddin, Bharat Biswal

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In this study, we examined structural and functional profiles of the insular cortex and mapped associations with well-described functional networks throughout the brain using diffusion tensor imaging (DTI) and resting-state functional connectivity (RSFC) data. We used a data-driven method to independently estimate the structural-functional connectivity of the insular cortex. Data were obtained from the Human Connectome Project comprising 108 adult participants. Overall, we observed moderate to high associations between the structural and functional mapping scores of 3 different insular subregions: The posterior insula (associated with the sensorimotor network: RSFC, DTI = 50% and 72%, respectively), dorsal anterior insula (associated with ventral attention: RSFC, DTI = 83% and 83%, respectively), and ventral anterior insula (associated with the frontoparietal: RSFC, DTI = 42% and 89%, respectively). Further analyses utilized meta-Analytic decoding maps to demonstrate specific cognitive and affective as well as gene expression profiles of the 3 subregions reflecting the core properties of the insular cortex. In summary, given the central role of the insular in the human brain, our results revealing correspondence between DTI and RSFC mappings provide a complementary approach and insight for clinical researchers to identify dysfunctional brain organization in various neurological disorders associated with insular pathology.

Original languageEnglish (US)
Pages (from-to)1726-1738
Number of pages13
JournalCerebral Cortex
Issue number5
StatePublished - Mar 1 2023

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


  • DTI
  • Human Connectome Project
  • insular
  • resting-state functional connectivity


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