Surface engineered excipients: I. improved functional properties of fine grade microcrystalline cellulose

Liang Chen, Xiaoyi Ding, Zizhou He, Zhonghui Huang, Kuriakose T. Kunnath, Kai Zheng, Rajesh N. Davé

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Excipients with good flowability, bulk density as well as compaction properties are desired for use in tableting since they play important roles in formulation development and processing, including, handling, mixing, feeding and compaction. The objective of this paper is to examine the feasibility of using dry coating based surface modification of microcrystalline cellulose, Avicel PH-105, to produce an engineered fine grade (<30 μm) excipient that has all three desired properties. Using a material sparing high-intensity vibrational mixer, Avciel PH-105 is dry coated with 1 wt% Aerosil 200, selected due to its relatively higher dispersive surface energy and lower particle size amongst other silica choices. The results indicated that as expected, the bulk density and flowability are significantly improved, while there was an appreciable loss of compaction. To minimize the loss of compaction, attributed to decreased surface energy after coating, while maintaining improved bulk density and flowability, the effect of reduced silica amount was examined. Remarkably, at reduced levels (0.5 wt% to 0.7 wt%) of Aerosil 200, significant improvements in bulk density and flowability were attained with only 9%–12% compaction reduction. The properties of the surface-engineered excipients were compared with several other commercially available pharmaceutical excipients using two different processibility or regime maps; tablet tensile strength versus bulk density or flow function coefficient (FFC). The surface engineered excipients exhibited the best overall performance establishing a promising pathway to engineer excipients using dry processing instead of complex processes such as spray drying.

Original languageEnglish (US)
Pages (from-to)127-137
Number of pages11
JournalInternational Journal of Pharmaceutics
Volume536
Issue number1
DOIs
StatePublished - Jan 30 2018

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Bulk density
  • Dry coating
  • Excipient
  • Powder flow
  • Silica
  • Surface modification
  • Tensile strength

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