Surface interactions affect the toxicity of engineered metal oxide nanoparticles toward Paramecium

Yongsheng Chen, Kungang Li, Ying Chen, Wen Zhang, Zhichao Pu, Lin Jiang

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

To better understand the potential impacts of engineered metal oxide nanoparticles (NPs) in the ecosystem, we investigated the acute toxicity of seven different types of engineered metal oxide NPs against Paramecium multimicronucleatum, a ciliated protozoan, using the 48 h LC50 (lethal concentration, 50%) test. Our results showed that the 48 h LC 50 values of these NPs to Paramecium ranged from 0.81 (Fe 2O3 NPs) to 9269 mg/L (Al2O3 NPs); their toxicity to Paramecium increased as follows: Al2O3 < TiO2 < CeO2 < ZnO < SiO2 < CuO < Fe2O3 NPs. On the basis of the Derjaguin-Landau- Verwey-Overbeek (DLVO) theory, interfacial interactions between NPs and cell membrane were evaluated, and the magnitude of interaction energy barrier correlated well with the 48 h LC50 data of NPs to Paramecium; this implies that metal oxide NPs with strong association with the cell surface might induce more severe cytotoxicity in unicellular organisms.

Original languageEnglish (US)
Pages (from-to)1675-1681
Number of pages7
JournalChemical Research in Toxicology
Volume25
Issue number8
DOIs
StatePublished - Aug 20 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Toxicology

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